KA Francoise (Kuan-Hua) A. Executive profile
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Lyon, France kuanhua.artignan@gmail.com

Technical leadership · Digital health · Bioinformatics

Francoise (Kuan-Hua) A.

Technical Director | Clinical & Biomedical Data | Interoperability, Digital Health & Bioinformatics

Technical Director specializing in AI-enabled healthcare, clinical and biomedical data, interoperability, and bioinformatics. I lead the design and delivery of digital health platforms, data pipelines, and products combining AI, clinical data, and multi-omics. My background spans software architecture, full-stack development, FHIR and medical terminologies, bioinformatics, data governance, and Agile product/project leadership. PMP®, PMI-ACP®, and ISO/IEC 27001:2022 Internal Auditor certified, I bridge clinical needs, business priorities, and technical decisions to build secure, traceable, production-ready systems.

PMP® — Project Management Professional PMI-ACP® — Agile Certified Practitioner ISO/IEC 27001:2022 — Lead Auditor Course
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Areas of expertise

Career

Professional Experience

09/2026 − Present Current

Freelance Technical Director | Digital Health, Clinical & Biomedical Data, Interoperability & Bioinformatics

MedcomAsia Bio-Technology Company, Taiwan — remote from France

Technologies: FHIR, SNOMED CT, LOINC, ICD, Python (FastAPI / Django / Flask), Java Spring Boot, React, Docker, PostgreSQL, MySQL, MongoDB, Keycloak, LLM / RAG

  • Continuing the technical direction of digital health and bioinformatics projects from France, focusing on technical strategy, architecture, product, and delivery without day-to-day administrative or HR responsibilities.
  • Defining technical directions, architectures, roadmaps, and development priorities based on clinical, business, and product needs.
  • Providing technical leadership to R&D, Data Science, MIS, and bioinformatics teams on architecture decisions, technical priorities, and complex problem solving.
  • Designing and evolving platforms integrating clinical, genomic, metabolomic, laboratory, imaging, and medical-device data with a strong focus on traceability, security, and data governance.
  • Interoperability and AI-ready data: FHIR-native DSDR registry, SNOMED CT / LOINC / ICD terminology mapping, and integration of HIS / LIS / PACS / device data flows.
  • Industrializing AI use cases through structured pipelines, report generation, human validation, prompt testing, and controls to reduce hallucinations and token costs.
  • Leading product delivery with Jira / Notion, aligning clinical and business requirements and supporting teams through deployment.
11/2023 − 08/2026 2 yrs 9 months

Head of IT Innovation | Digital Health, Data & Bioinformatics

MedcomAsia Bio-Technology Company, Taiwan

Technologies: Java (Spring Boot / Spring AI), Python (Flask / FastAPI / Django), React, TypeScript, Docker, GitLab CI/CD, PostgreSQL, MySQL, MongoDB, Neo4j, GraphQL, Keycloak, RDF / SPARQL, FHIR

  • Led the IT Innovation department with management of R&D, Data Science, and MIS teams, setting priorities and coordinating technical and business stakeholders.
  • Managed roadmaps, backlogs, sprints, and deliverables with Jira and Notion in an Agile environment.
  • Designed a data collection and integration architecture for a precision-medicine clinic, connecting clinical systems, health-check devices, and heterogeneous data sources with traceable and secure data flows.
  • Led a FHIR-native DSDR registry and participated with the team in Connectathon 2026 (tracks 2 and 3) to test FHIR-based exchanges.
  • Designed a secure data pipeline transforming clinical, genomic, and multi-omics data into structured, standardized, traceable, AI-ready datasets.
  • Architected WGS / WES platforms and bioinformatics pipelines, APIs, and reporting modules for clinical and research use.
  • Implemented IAM with Keycloak, CI/CD practices, and security governance for healthcare-data environments.
02/2023 - 07/2023 6 months

Internship

France, LBBE (Laboratory of Biometry and Evolutionary Biology)

Technologies: HTML, CSS, JS, jQuery, Python Flask, Docker, Singularity, Unix, Snakemake

Re-architected the DGINN pipeline with Snakemake; created an API to make the pipeline accessible to biologists.

  • Rebuilt DGINN pipeline with Snakemake
  • Built an API with Python Flask (server) and HTML / CSS / JS / jQuery (frontend); containerized with Docker
  • Edited a scientific manuscript in French
2022/09 - 2022/12

Analyzing Spotify Music Data with Machine Learning and Pattern Mining (Project)

Technology: Python

ML course project (pair programming).

2020/09 - 2022/07 2 years

End-to-End Bioinformatics Data Platform Development (Full-Stack)

GAD (Génétique des Anomalies du Développement) – University Hospital (CHU) of Dijon, France

Technologies: Python, Flask, JavaScript, HTML, CSS, jQuery, MongoDB, Unix, Apache (internal preprod / server environment), Java, qsub (HPC scheduling)

  • Designed and developed a web-based bioinformatics platform for clinical and research use, supporting large-scale genome / exome sequencing analysis and visualization.
  • Built an end-to-end data pipeline using Python and MongoDB for patient-derived variant processing and querying.
  • Developed interactive visualization tools and dynamic UIs with JavaScript / jQuery for geneticists and clinicians.
  • Enhanced Java tools to strengthen ETL preprocessing and consistency.
  • Deployed within the hospital’s Unix servers to ensure security and performance.
  • Used qsub job scheduling on HPC clusters for batch processing and optimized resource allocation.
  • Proficient with Unix command-line operations for automation, monitoring, and maintenance.
  • Provided on-call support for data workflows, including maintenance, troubleshooting, and tool updates.
Earlier experience +
06/2016 - 06/2019 3 years

Administrative Secretary & Project Assistant

Formosa IT Training — Lyon, France

Technologies: HTML, PHP, CSS, JavaScript, SQL

Formosa is an IT professional training organization; supported course and project management, instructor enablement, and operations.

  • Managed administration, HR, and course scheduling; supported PMs and instructors in curriculum planning.
  • Coordinated communication between clients and technical teams to keep projects on track.
  • Applied Agile mindset to multitasking; set up standardized documentation and task tracking.
  • Built a foundation for later Product Owner cross-functional collaboration and leadership.
2012-2013 6 months

Substitute English Teacher

Cha-Chiao Elementary School, Jin-Min Branch — Sanxia, New Taipei City, Taiwan (R.O.C.)

Taught English to grades 1–6 (ages 7–12); supported library and data cataloging tasks.

08/2010 - 08/2011 1 year (full-time)

HR & Administration

Sanxia District Church Foundation — New Taipei City

Social welfare services, documentation and data processing, youth mentoring, and life-education classes on campus.

09/2006 - 06/2007 10 months (part-time)

Teaching Assistant — Biostatistics

Public Health Laboratory — China Medical University — Taichung, Taiwan (R.O.C.)

Supported the Biostatistics Center teaching activities: 1. Data querying and integration 2. Statistical analysis and SAS teaching materials 3. Literature searches 4. Hospital questionnaire surveys as research data

09/2006 - 06/2007 10 months (part-time)

Clinical Research — Practical Data Processing

Biostatistics Center — China Medical University — Taichung, Taiwan (R.O.C.)

Performed data processing and statistical analysis using SAS, SPSS, and R; supported course preparation and materials.

2005/09 - 2006/06 10 months (part-time)

Assistant to Professor — Environmental Sciences

Public Health Laboratory — China Medical University (Taichung, Taiwan)

Supported microbiology research and contributed to GIS-based analyses for environmental applications.

Expertise

Technical Skills — Details

Product Ownership & Systems Architecture

Agile / Scrum / Kanban — project and delivery management Product Backlog / User Stories / Sprint planning and execution Layered and modular architecture design Stakeholder communication and cross-functional collaboration (Engineering, Bioinformatics, AI) Business model design and operations strategy Requirements interviews, process analysis, UX / UI wireframing

NGS Analysis

RNA-seq, ChIP-seq, resequencing, metagenomics WGS (whole-genome) & WES (exome) Pipelines: Snakemake, Bash (Shell)

Coding Languages

Python Java C++

Data Visualization

Python (matplotlib, scikit-learn, Dash, Biopython, pandas, GeoPandas, etc.) R (Shiny)

Data Analysis

Machine Learning LLM / AI / NLP (prompt engineering, RAG / GraphRAG, evaluation) Pattern mining Big data: PySpark, Node.js Statistical software: R / R Shiny Statistical software: SAS, SPSS

Databases

MongoDB MySQL, PostgreSQL Neo4j (graph database) RDF, SPARQL, ORM, XML, GraphQL

Front-End Development

HTML, CSS, JavaScript Jinja2 jQuery, Angular React, TypeScript

Back-End Development

Python / Flask Python / Django Java / Spring Boot

Business Intelligence (BI) & Data Integration

Talend (ETL, field mapping, scheduling) Python ETL: pandas, FHIR API (fhir.resources), REST ingestion and transformation

System Deployment

Linux / Unix Windows

Frequently Used Technical Skills

GitLab / GitHub Conda (environment management) Docker Keycloak (SSO / IdP: OIDC, SAML, RBAC) Cloud (Biosphere / Google / Amazon) / NVIDIA Parabricks CI / CD K8s (Kubernetes) Unit testing

Education

Training and Diplomas

2020 - 2023

Master Degree - Bioinfomatique - University of Claude Bernard Lyon 1

2019 - 2020

Bachelors of Science, Technology, Health - Bio-Informatique, Statistique et Modelisation - University of Claude Bernard Lyon 1

2018 - 2019

Professional IT training - Company of Formosa (IT training)

program : SQL, Java, Talend, HTML/CSS, JS, Responsive Design

2011

Teacher Training Program in Chinese as a Foreign Language

2006 - 2007

Teaching Assistant Service - Practical Data Processing - China Medical University, Taichung, Taiwan (R.O.C)

2007

Bachelors of Science - Department of Risk Management - College of Public Health - China Medical University, Taichung, Taiwan (R.O.C)

2002

High School Degree - Taipei Municipal Ching-Mei Girls' Senior High School, Taiwan (R.O.C)

Selected work

Conferences & Projects

September – December 2022

Master’s Project – EcoFood API

Technologies: Python, Flask, Web API, PostgreSQL

Public health research: developed an API to calculate the carbon footprint of Crous meals.

September – November 2022

Data Visualization of Mega-Data

Technologies: Python, Web API, R Shiny, SQL

Interactive visualization of air pollution data in France

2020 – 2022

SCNVBase Project

Technologies: MongoDB, Python Flask, HTML, CSS, JavaScript, jQuery, Apache; quality-control server

Developed a Python API using a three-tier architecture to visualize genomic variant data, implemented JWT authentication and security mechanisms, and presented project results to clinicians and biologists.

2020

Faculty Bioinformatics Project

Technologies: Python, Biopython

Implemented the Needleman–Wunsch and Smith–Waterman algorithms; performed annotation and NGS mapping.

2018

Website Interface Development

Technologies: HTML, CSS, Bootstrap, JavaScript, MySQL, PHP

Developed the website front-end interface and content management system for a foundation.