Francoise (Kuan-Hua) A.

Technical Skills

• AI-Driven Healthcare Platform / System Architecture
• NGS Analysis (Next-Generation Sequencing)
• Databases: PostgreSQL, MySQL, MongoDB, Neo4j
• Frontend Development (React, Angular, TypeScript)
• Backend Development (Java Spring Boot / Spring AI, Flask / FastAPI / Django)
• Data Visualization (matplotlib, Dash, R Shiny)
• Data Analysis & Machine Learning
• Artificial Intelligence / Large Language Models (RAG / GraphRAG, Prompt Engineering, Model Evaluation)
• Knowledge Graphs & Data Interoperability (RDF / SPARQL, GraphQL, FHIR)
• DevOps & CI/CD (Docker, GitLab CI, Automated Monitoring)
• Identity & Access Management (Keycloak SSO: OIDC / SAML, RBAC)

languages

• French Very fluent
• English Fluent
• Chinese Mother tongue
• Japanese Reactive

Professional Experience

• 2023/11 − Present

  IT & Bioinformatics Manager | Product Owner (PO) / System Architect & Project Designer

  MedcomAsia Bio-Technology Company, Taiwan

  Technologies: Java (Spring Boot / Spring AI), Python (Flask / FastAPI / Django), React, Angular, TypeScript, Docker, GitLab CI/CD, PostgreSQL, MySQL, MongoDB, Neo4j, GraphQL, Keycloak, RDF / SPARQL, FHIR

  • Product Owner: define product vision and roadmap; manage Backlog / User Stories / Sprints with Agile practices.
  • Designed WGSpark architecture: pipeline, APIs, and reporting modules; standardized WGS / WES / Panel analysis workflows.
  • Planned SciTarget platform: built a JCR metrics repository and a submission strategy recommendation engine.
  • Led FHIR-based ETL and resource modeling system design.
  • Built AI decision support: integrated genomic and clinical data; applied LLM + RAG / GraphRAG / OpenAI token workflows to prediction and reasoning, improving accuracy and clinical interpretability.
  • Genomics–clinical integration: fused NGS / epigenetic / clinical data to build predictive and decision support systems.
  • Orchestrated cross-functional delivery: aligned IT, Bioinformatics, and Clinical; defined data flow, FHIR standardization, and model development lifecycle.
  • Established knowledge graphs: RDF / SPARQL / Neo4j / GraphQL with SNOMED CT / LOINC / ICD terminology mapping.
  • Integrated Keycloak (SSO / OIDC / SAML / RBAC); defined CI/CD, DevOps, security governance, and model deployment processes.
  • Built Bio-DevOps: Snakemake / Nextflow + GitLab CI + Docker for reproducible pipelines and provenance.
  • Designed a Hybrid SaaS business model: on-prem MCA Server runs LLM + RAG / GraphRAG and model updates; Edge Nodes (hospital) collect and preprocess data; licensing + managed service subscription.
  

  Current
• 02/2023 - 07/2023

  Internship

  France, LBBE (Laboratory of Biometry and Evolutionary Biology)

  Technologies: HTML, CSS, JS, jQuery, Python Flask, Docker, Singularity, Unix, Snakemake

  Re-architected the DGINN pipeline with Snakemake; created an API to make the pipeline accessible to biologists.
  • Rebuilt DGINN pipeline with Snakemake
  • Built an API with Python Flask (server) and HTML / CSS / JS / jQuery (frontend); containerized with Docker
  • Edited a scientific manuscript in French

  6 months
• 2022/09 - 2022/12

  Analyzing Spotify Music Data with Machine Learning and Pattern Mining (Project)

  Technology: Python

  ML course project (pair programming).
  

• 2020/09 - 2022/07

  End-to-End Bioinformatics Data Platform Development (Full-Stack)

  GAD (Génétique des Anomalies du Développement) – University Hospital (CHU) of Dijon, France

  Technologies: Python, Flask, JavaScript, HTML, CSS, jQuery, MongoDB, Unix, Apache (internal preprod / server environment), Java, qsub (HPC scheduling)

  • Designed and developed a web-based bioinformatics platform for clinical and research use, supporting large-scale genome / exome sequencing analysis and visualization.
  • Built an end-to-end data pipeline using Python and MongoDB for patient-derived variant processing and querying.
  • Developed interactive visualization tools and dynamic UIs with JavaScript / jQuery for geneticists and clinicians.
  • Enhanced Java tools to strengthen ETL preprocessing and consistency.
  • Deployed within the hospital’s Unix servers to ensure security and performance.
  • Used qsub job scheduling on HPC clusters for batch processing and optimized resource allocation.
  • Proficient with Unix command-line operations for automation, monitoring, and maintenance.
  • Provided on-call support for data workflows, including maintenance, troubleshooting, and tool updates.

  2 years
• 06/2016 - 06/2019

  Administrative Secretary & Project Assistant

  Formosa IT Training — Lyon, France

  Technologies: HTML, PHP, CSS, JavaScript, SQL

  Formosa is an IT professional training organization; supported course and project management, instructor enablement, and operations.
  • Managed administration, HR, and course scheduling; supported PMs and instructors in curriculum planning.
  • Coordinated communication between clients and technical teams to keep projects on track.
  • Applied Agile mindset to multitasking; set up standardized documentation and task tracking.
  • Built a foundation for later Product Owner cross-functional collaboration and leadership.

  3 years
• 2012-2013

  Substitute English Teacher

  Cha-Chiao Elementary School, Jin-Min Branch — Sanxia, New Taipei City, Taiwan (R.O.C.)

  Taught English to grades 1–6 (ages 7–12); supported library and data cataloging tasks.

  6 months
• 08/2010 - 08/2011

  HR & Administration

  Sanxia District Church Foundation — New Taipei City

  Social welfare services, documentation and data processing, youth mentoring, and life-education classes on campus.

  1 year (full-time)
• 09/2006 - 06/2007

  Teaching Assistant — Biostatistics

  Public Health Laboratory — China Medical University — Taichung, Taiwan (R.O.C.)

  Supported the Biostatistics Center teaching activities:
  1. Data querying and integration
  2. Statistical analysis and SAS teaching materials
  3. Literature searches
  4. Hospital questionnaire surveys as research data

  10 months (part-time)
• 09/2006 - 06/2007

  Clinical Research — Practical Data Processing

  Biostatistics Center — China Medical University — Taichung, Taiwan (R.O.C.)

  Performed data processing and statistical analysis using SAS, SPSS, and R; supported course preparation and materials.

  10 months (part-time)
• 2005/09 - 2006/06

  Assistant to Professor — Environmental Sciences

  Public Health Laboratory — China Medical University (Taichung, Taiwan)

  Supported microbiology research and contributed to GIS-based analyses for environmental applications.

  10 months (part-time)

Training and Diplomas

• 2020 - 2023

  Master Degree - Bioinfomatique - University of Claude Bernard Lyon 1

• 2019 - 2020

  Bachelors of Science, Technology, Health - Bio-Informatique, Statistique et Modelisation - University of Claude Bernard Lyon 1

• 2018 - 2019

  Professional IT training - Company of Formosa (IT training)

  program : SQL, Java, Talend, HTML/CSS, JS, Responsive Design

• 2011

  Teacher Training Program in Chinese as a Foreign Language

• 2006 - 2007

  Teaching Assistant Service - Practical Data Processing - China Medical University, Taichung, Taiwan (R.O.C)

• 2007

  Bachelors of Science - Department of Risk Management - College of Public Health - China Medical University, Taichung, Taiwan (R.O.C)

• 2002

  High School Degree - Taipei Municipal Ching-Mei Girls' Senior High School, Taiwan (R.O.C)

Conferences & Projects

• September – December 2022

  Master’s Project – EcoFood API

  Technologies: Python, Flask, Web API, PostgreSQL

  Public health research: developed an API to calculate the carbon footprint of Crous meals.

• September – November 2022

  Data Visualization of Mega-Data

  Technologies: Python, Web API, R Shiny, SQL

  Interactive visualization of air pollution data in France

• February 1–4, 2022

  Conference: French Annual Meeting of Genetics and Medical Genetics, Rennes

  “Innovative Human Genetics Database: SCNVBase for storing human genomic variant data.” Authors: Kuan-Hua Artignan, Yannis Duffourd, et al. (Poster N°28146)

• 2020 – 2022

  SCNVBase Project

  Technologies: MongoDB, Python Flask, HTML, CSS, JavaScript, jQuery, Apache; quality-control server

  Developed a Python API using a three-tier architecture to visualize genomic variant data, implemented JWT authentication and security mechanisms, and presented project results to clinicians and biologists.

• 2020

  Faculty Bioinformatics Project

  Technologies: Python, Biopython

  Implemented the Needleman–Wunsch and Smith–Waterman algorithms; performed annotation and NGS mapping.

• 2018

  Website Interface Development

  Technologies: HTML, CSS, Bootstrap, JavaScript, MySQL, PHP

  Developed the website front-end interface and content management system for a foundation.